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Make sure to also tell your doctor about any other medications you may be taking that may not mix too well with colchicine and create havoc for your health.
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Advise patients that many drugs or other substances may interact with colchicine capsules and some interactions could be fatal.
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Fatal overdoses, both accidental and intentional, have been reported in adults and children who have ingested colchicine see overdose .
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It is often assumed that microtubule disruption by colchicine is poorly reversible; thus, most experiments are performed in control conditions on colchicine-treated cells.
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Colchicine is an alkaloid chemical derived from a flowering bulb of the lily family that is known as the autumn crocus colchicum autumnale .
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, as well as the 40 increase in systemic levels of colchicine observed with concomitantly administered fluconazole a moderate cyp3a4 inhibitor that is not known to inhibit p-gp in a drug-drug interaction study, the drug-drug interaction potential of colchicine with strong or moderate cyp3a4 inhibitors that do not inhibit p-gp cannot be ruled out completely.
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